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PDK1 Homologs Activate the Pkc1–Mitogen-Activated Protein Kinase Pathway in Yeast

PDK1 (phosphoinositide-dependent kinase 1) is a mammalian growth factor-regulated serine/threonine kinase. Using a genetic selection based on a mutant form of the yeast MAP kinase kinase Ste7, we isolated a gene, PKH2, encoding a structurally and functionally conserved yeast homolog of PDK1. Yeast c...

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Udgivet i:Mol Cell Biol
Principais autores: Inagaki, Maiko, Schmelzle, Tobias, Yamaguchi, Kyoko, Irie, Kenji, Hall, Michael N., Matsumoto, Kunihiro
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1999
Fag:
Cell Growth and Development
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84921/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10567559/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.12.8344
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