The Oncogenic 70Z Cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells

T-cell receptor (TCR) engagement results in the activation of Src family (Lck and Fyn) and ZAP-70 protein tyrosine kinases, leading to tyrosine phosphorylation of multiple cellular substrates including the complex adapter protein c-Cbl. Moreover, Cbl is tyrosine phosphorylated upon engagement of gro...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	van Leeuwen, Jeroen E. M., Paik, Paul K., Samelson, Lawrence E.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84647/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10490604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.10.6652
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