Two Inactive Fragments of the Integral RNA Cooperate To Assemble Active Telomerase with the Human Protein Catalytic Subunit (hTERT) In Vitro

We have mapped the 5′ and 3′ boundaries of the region of the human telomerase RNA (hTR) that is required to produce activity with the human protein catalytic subunit (hTERT) by using in vitro assembly systems derived from rabbit reticulocyte lysates and human cell extracts. The region spanning nucle...

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Detalhes bibliográficos
Main Authors: Tesmer, Valerie M., Ford, Lance P., Holt, Shawn E., Frank, Bryan C., Yi, Xiaoming, Aisner, Dara L., Ouellette, Michel, Shay, Jerry W., Wright, Woodring E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC84565/
https://ncbi.nlm.nih.gov/pubmed/10454567
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