Two Inactive Fragments of the Integral RNA Cooperate To Assemble Active Telomerase with the Human Protein Catalytic Subunit (hTERT) In Vitro

We have mapped the 5′ and 3′ boundaries of the region of the human telomerase RNA (hTR) that is required to produce activity with the human protein catalytic subunit (hTERT) by using in vitro assembly systems derived from rabbit reticulocyte lysates and human cell extracts. The region spanning nucle...

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Autori principali: Tesmer, Valerie M., Ford, Lance P., Holt, Shawn E., Frank, Bryan C., Yi, Xiaoming, Aisner, Dara L., Ouellette, Michel, Shay, Jerry W., Wright, Woodring E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
Soggetti:
Cell Growth and Development
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC84565/
https://ncbi.nlm.nih.gov/pubmed/10454567
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