The Linker Domain of Stat1 Is Required for Gamma Interferon-Driven Transcription

Upon binding of gamma interferon (IFN-γ) to its receptor, the latent transcription factor Stat1 becomes phosphorylated, dimerizes, and enters the nucleus to activate transcription. In response to IFN-α, Stat1 binds to Stat2 in a heterodimer that recruits p48, an IRF family member, to activate transc...

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Bibliographic Details
Main Authors: Yang, Edward, Wen, Zilong, Haspel, Richard L., Zhang, Jue J., Darnell, James E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84353/
https://ncbi.nlm.nih.gov/pubmed/10373559
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