Domain Swapping Used To Investigate the Mechanism of Protein Kinase B Regulation by 3-Phosphoinositide-Dependent Protein Kinase 1 and Ser473 Kinase

Protein kinase B (PKB or Akt), a downstream effector of phosphoinositide 3-kinase (PI 3-kinase), has been implicated in insulin signaling and cell survival. PKB is regulated by phosphorylation on Thr308 by 3-phosphoinositide-dependent protein kinase 1 (PDK1) and on Ser473 by an unidentified kinase....

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Andjelković, Mirjana, Maira, Sauveur-Michel, Cron, Peter, Parker, Peter J., Hemmings, Brian A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84347/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10373555/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.7.5061
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