Physiological Requirement for Both SH2 Domains for Phospholipase C-γ1 Function and Interaction with Platelet-Derived Growth Factor Receptors

Two approaches have been utilized to investigate the role of individual SH2 domains in growth factor activation of phospholipase C-γ1 (PLC-γ1). Surface plasmon resonance analysis indicates that the individual N-SH2 and C-SH2 domains are able to specifically recognize a phosphotyrosine-containing pep...

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Bibliographic Details
Main Authors: Ji, Qun-sheng, Chattopadhyay, Ansuman, Vecchi, Manuela, Carpenter, Graham
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC84312/
https://ncbi.nlm.nih.gov/pubmed/10373546
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