The Saccharomyces cerevisiae Hyperrecombination Mutant hpr1Δ Is Synthetically Lethal with Two Conditional Alleles of the Acetyl Coenzyme A Carboxylase Gene and Causes a Defect in Nuclear Export of Polyadenylated RNA

In a screen for mutants that display synthetic lethal interaction with hpr1Δ, a hyperrecombination mutant of Saccharomyces cerevisiae, we have isolated a novel cold-sensitive allele of the acetyl coenzyme A (CoA) carboxylase gene, acc1(cs), encoding the rate-limiting enzyme of fatty acid synthesis....

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Main Authors: Schneiter, Roger, Guerra, Cesar E., Lampl, Manfred, Gogg, Gabriela, Kohlwein, Sepp D., Klein, Hannah L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Gene Expression
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC84134/
https://ncbi.nlm.nih.gov/pubmed/10207065
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