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5-Azacytidine Induces Transgene Silencing by DNA Methylation in Chinese Hamster Cells

The cytosine analog 5-azacytidine (5-AzaC) is a demethylating agent that is also known to induce mutagenesis in mammalian cells. In this study, the mutagenic potential of this drug was tested in the G10 and G12 transgenic Chinese hamster cell lines, which have a single bacterial gpt gene integrated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Broday, Limor, Lee, Yong-Woo, Costa, Max
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84113/
https://ncbi.nlm.nih.gov/pubmed/10082586
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