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Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

The Smads are a family of nine related proteins which function as signaling intermediates for the transforming growth factor β (TGF-β) superfamily of ligands. To discern the in vivo functions of one of these Smads, Smad3, we generated mice harboring a targeted disruption of this gene. Smad3 null mic...

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Bibliografiske detaljer
Main Authors: Datto, Michael B., Frederick, Joshua P., Pan, Lihua, Borton, Anita J., Zhuang, Yuan, Wang, Xiao-Fan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84042/
https://ncbi.nlm.nih.gov/pubmed/10082515
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