Analysis of Genomic Integrity and p53-Dependent G(1) Checkpoint in Telomerase-Induced Extended-Life-Span Human Fibroblasts

Life span determination in normal human cells may be regulated by nucleoprotein structures called telomeres, the physical ends of eukaryotic chromosomes. Telomeres have been shown to be essential for chromosome stability and function and to shorten with each cell division in normal human cells in cu...

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Bibliografiske detaljer
Main Authors: Vaziri, Homayoun, Squire, Jeremy A., Pandita, Tej K., Bradley, Grace, Kuba, Robert M., Zhang, Haihua, Gulyas, Sandor, Hill, Richard P., Nolan, Garry P., Benchimol, Samuel
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC84029/
https://ncbi.nlm.nih.gov/pubmed/10022923
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