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Cell Cycle-Dependent Regulation of Human DNA Polymerase α-Primase Activity by Phosphorylation

DNA polymerase α-primase is known to be phosphorylated in human and yeast cells in a cell cycle-dependent manner on the p180 and p68 subunits. Here we show that phosphorylation of purified human DNA polymerase α-primase by purified cyclin A/cdk2 in vitro reduced its ability to initiate simian virus...

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Udgivet i:Mol Cell Biol
Principais autores: Voitenleitner, Christian, Rehfuess, Christoph, Hilmes, Melissa, O’Rear, Lynda, Liao, Pao-Chi, Gage, Douglas A., Ott, Robert, Nasheuer, Heinz-Peter, Fanning, Ellen
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1999
Fag:
DNA Dynamics and Chromosome Structure
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83922/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9858588/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.1.646
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