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NAD(+) precursor modulates post-ischemic mitochondrial fragmentation and reactive oxygen species generation via SIRT3 dependent mechanisms

Global cerebral ischemia depletes brain tissue NAD(+), an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD(+) levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a pr...

詳細記述

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書誌詳細
出版年:Exp Neurol
主要な著者: Klimova, Nina, Fearnow, Adam, Long, Aaron, Kristian, Tibor
フォーマット: Artigo
言語:Inglês
出版事項: 2019
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328278/
https://ncbi.nlm.nih.gov/pubmed/31837320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.113144
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