SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8 T cells

Although mRNA vaccine efficacy against severe COVID-19 remains high, variant emergence and breakthrough infections have changed vaccine policy to include booster immunizations. However, the effect of diverse and repeated antigen exposures on SARS-CoV-2 memory T cells is poorly understood. Here, we u...

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Foilsithe in:medRxiv
Main Authors: Minervina, Anastasia A., Pogorelyy, Mikhail V., Kirk, Allison M., Crawford, Jeremy Chase, Allen, E. Kaitlynn, Chou, Ching-Heng, Mettelman, Robert C., Allison, Kim J., Lin, Chun-Yang, Brice, David C., Zhu, Xun, Vegesana, Kasi, Wu, Gang, Trivedi, Sanchit, Kottapalli, Pratibha, Darnell, Daniel, McNeely, Suzanne, Olsen, Scott R., Schultz-Cherry, Stacey, Estepp, Jeremie H., McGargill, Maureen A., Wolf, Joshua, Thomas, Paul G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory 2022
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8328067/
https://ncbi.nlm.nih.gov/pubmed/34341799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.07.12.21260227
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