MicroRNA-138-1-3p sensitizes sorafenib to hepatocellular carcinoma by targeting PAK5 mediated β-catenin/ABCB1 signaling pathway

BACKGROUND: Sorafenib is a kinase inhibitor that is used as a first-line therapy in advanced hepatocellular carcinoma (HCC) patients. However, the existence of sorafenib resistance has limited its therapeutic effect. Through RNA sequencing, we demonstrated that miR-138-1-3p was downregulated in sora...

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Dades bibliogràfiques
Publicat a:J Biomed Sci
Autors principals: Li, Tong-tong, Mou, Jie, Pan, Yao-jie, Huo, Fu-chun, Du, Wen-qi, Liang, Jia, Wang, Yang, Zhang, Lan-sheng, Pei, Dong-sheng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327419/
https://ncbi.nlm.nih.gov/pubmed/34340705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-021-00752-4
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