ITPA:c.94C>A and NUDT15:c.415C>T Polymorphisms and Their Relation to Mercaptopurine-Related Myelotoxicity in Childhood Leukemia in Thailand

BACKGROUND: Mercaptopurine is a key agent in childhood leukemia treatment. Genetic polymorphism in the genes involving thiopurine metabolisms is related to 6-MP related toxicity. OBJECTIVE: This study aimed to determine the prevalence of ITPA:c.94C>A and NUDT15:c.415C>T polymorphisms among Tha...

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Detalhes bibliográficos
Publicado no:Appl Clin Genet
Main Authors: Boonyawat, Boonchai, Monsereenusorn, Chalinee, Photia, Apichat, Lertvivatpong, Nawachai, Kaewchaivijit, Varissara, Jindatanmanusan, Punyanuch, Rujkijyanont, Piya
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2021
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326781/
https://ncbi.nlm.nih.gov/pubmed/34349542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/TACG.S318912
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