Plasma Citrate and Succinate Are Associated With Neurocognitive Impairment in Older People With HIV

BACKGROUND: Neurocognitive impairment (NCI) is associated with monocyte activation in people with HIV (PWH). Activated monocytes increase glycolysis, reduce oxidative phosphorylation, and accumulate citrate and succinate, tricarboxylic acid (TCA) cycle metabolites that promote inflammation—this meta...

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Detalhes bibliográficos
Publicado no:Clin Infect Dis
Main Authors: Hileman, Corrilynn O, Kalayjian, Robert C, Azzam, Sausan, Schlatzer, Daniela, Wu, Kunling, Tassiopoulos, Katherine, Bedimo, Roger, Ellis, Ronald J, Erlandson, Kristine M, Kallianpur, Asha, Koletar, Susan L, Landay, Alan L, Palella, Frank J, Taiwo, Babafemi, Pallaki, Muralidhar, Hoppel, Charles L
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Online Only Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326582/
https://ncbi.nlm.nih.gov/pubmed/33564870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciab107
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