Plasma Citrate and Succinate Are Associated With Neurocognitive Impairment in Older People With HIV

BACKGROUND: Neurocognitive impairment (NCI) is associated with monocyte activation in people with HIV (PWH). Activated monocytes increase glycolysis, reduce oxidative phosphorylation, and accumulate citrate and succinate, tricarboxylic acid (TCA) cycle metabolites that promote inflammation—this meta...

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Détails bibliographiques
Publié dans:Clin Infect Dis
Auteurs principaux: Hileman, Corrilynn O, Kalayjian, Robert C, Azzam, Sausan, Schlatzer, Daniela, Wu, Kunling, Tassiopoulos, Katherine, Bedimo, Roger, Ellis, Ronald J, Erlandson, Kristine M, Kallianpur, Asha, Koletar, Susan L, Landay, Alan L, Palella, Frank J, Taiwo, Babafemi, Pallaki, Muralidhar, Hoppel, Charles L
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2021
Sujets:
Online Only Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326582/
https://ncbi.nlm.nih.gov/pubmed/33564870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciab107
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