Galectin-3 promotes noncanonical inflammasome activation through intracellular binding to lipopolysaccharide glycans

Cytosolic lipopolysaccharides (LPSs) bind directly to caspase-4/5/11 through their lipid A moiety, inducing inflammatory caspase oligomerization and activation, which is identified as the noncanonical inflammasome pathway. Galectins, β-galactoside–binding proteins, bind to various gram-negative bact...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Lo, Tzu-Han, Chen, Hung-Lin, Yao, Cheng-I, Weng, I-Chun, Li, Chi-Shan, Huang, Chi-Chun, Chen, Nien-Jung, Lin, Chun-Hung, Liu, Fu-Tong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325309/
https://ncbi.nlm.nih.gov/pubmed/34301890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2026246118
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