Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across

The recent approval of messenger RNA (mRNA)-based vaccines to combat the SARS-CoV-2 pandemic highlights the potential of both conventional mRNA and self-amplifying mRNA (saRNA) as a flexible immunotherapy platform to treat infectious diseases. Besides the antigen it encodes, mRNA itself has an immun...

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Publicado no:Adv Drug Deliv Rev
Main Authors: Minnaert, An-Katrien, Vanluchene, Helena, Verbeke, Rein, Lentacker, Ine, De Smedt, Stefaan C., Raemdonck, Koen, Sanders, Niek N., Remaut, Katrien
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier B.V. 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8325057/
https://ncbi.nlm.nih.gov/pubmed/34324884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.addr.2021.113900
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