Structural basis for +1 ribosomal frameshifting during EF-G-catalyzed translocation

Frameshifting of mRNA during translation provides a strategy to expand the coding repertoire of cells and viruses. How and where in the elongation cycle +1-frameshifting occurs remains poorly understood. We describe seven ~3.5-Å-resolution cryo-EM structures of 70S ribosome complexes, allowing visua...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Demo, Gabriel, Gamper, Howard B., Loveland, Anna B., Masuda, Isao, Carbone, Christine E., Svidritskiy, Egor, Hou, Ya-Ming, Korostelev, Andrei A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324841/
https://ncbi.nlm.nih.gov/pubmed/34330903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24911-1
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