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The TNFRSF11B mutation associated with calcium pyrophosphate deposition disease results in ineffective osteoclast suppression
OBJECTIVES: TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate deposition disease (CPDD). While the CCAL1 OPG mutation (OPG-XL) was originally believed to be a gain-of-function, loss of OPG activity causes arthrit...
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| Veröffentlicht in: | Arthritis Rheumatol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8324507/ https://ncbi.nlm.nih.gov/pubmed/33559312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41678 |
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