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The TNFRSF11B mutation associated with calcium pyrophosphate deposition disease results in ineffective osteoclast suppression

OBJECTIVES: TNFRSF11B encodes for osteoprotegerin (OPG) and was recently identified as the CCAL1 locus associated with familial calcium pyrophosphate deposition disease (CPDD). While the CCAL1 OPG mutation (OPG-XL) was originally believed to be a gain-of-function, loss of OPG activity causes arthrit...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Mitton-Fitzgerald, Elizabeth, Gohr, Claudia M., Williams, Charlene J, Ortiz, Amaryllis, Mbalaviele, Gabriel, Rosenthal, Ann K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8324507/
https://ncbi.nlm.nih.gov/pubmed/33559312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.41678
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