Automated AI labeling of optic nerve head enables insights into cross-ancestry glaucoma risk and genetic discovery in >280,000 images from UKB and CLSA

Cupping of the optic nerve head, a highly heritable trait, is a hallmark of glaucomatous optic neuropathy. Two key parameters are vertical cup-to-disc ratio (VCDR) and vertical disc diameter (VDD). However, manual assessment often suffers from poor accuracy and is time intensive. Here, we show convo...

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Detalhes bibliográficos
Publicado no:Am J Hum Genet
Main Authors: Han, Xikun, Steven, Kaiah, Qassim, Ayub, Marshall, Henry N., Bean, Cameron, Tremeer, Michael, An, Jiyuan, Siggs, Owen M., Gharahkhani, Puya, Craig, Jamie E., Hewitt, Alex W., Trzaskowski, Maciej, MacGregor, Stuart
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322932/
https://ncbi.nlm.nih.gov/pubmed/34077762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.05.005
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