Thymic Involution and Altered Naive CD4 T Cell Homeostasis in Neuromyelitis Optica Spectrum Disorder

Circulating T helper cells with a type 17-polarized phenotype (TH17) and expansion of aquaporin-4 (AQP4)-specific T cells are frequently observed in patients with neuromyelitis optica spectrum disorder (NMOSD). However, naive T cell populations, which give rise to T helper cells, and the primary sit...

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Udgivet i:Front Immunol
Main Authors: Chang, Haoxiao, Cong, Hengri, Wang, Huabing, Du, Li, Tian, De-Cai, Ma, Yuetao, Xu, Yun, Wang, Yupeng, Yin, Linlin, Zhang, Xinghu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322781/
https://ncbi.nlm.nih.gov/pubmed/34335563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.645277
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