Chronic activation of 4-1BB signaling induces granuloma development in tumor-draining lymph nodes that is detrimental to subsequent CD8(+) T cell responses

The antitumor capabilities of agonistic anti-4-1BB mAbs have made them an attractive target for tumor immunotherapy. However, the adverse side effects associated with agonist antibodies have hindered their clinical development. Here, we aimed to study the immune-related adverse events of repeated do...

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Detalhes bibliográficos
Publicado no:Cell Mol Immunol
Main Authors: Kim, Seon-Hee, Singh, Rohit, Han, Chungyong, Cho, Eunjung, Kim, Yu I., Lee, Don G., Kim, Young H., Kim, Sang Soo, Shin, Dong Hoon, You, Hye Jin, Lee, Hyeon-Woo, Kwon, Byoung S., Choi, Beom K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8322392/
https://ncbi.nlm.nih.gov/pubmed/32868911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-020-00533-3
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