Reverse Plasticity Underlies Rapid Evolution by Clonal Selection within Populations of Fibroblasts Propagated on a Novel Soft Substrate

Mechanical properties such as substrate stiffness are a ubiquitous feature of a cell’s environment. Many types of animal cells exhibit canonical phenotypic plasticity when grown on substrates of differing stiffness, in vitro and in vivo. Whether such plasticity is a multivariate optimum due to hundr...

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Detalhes bibliográficos
Publicado no:Mol Biol Evol
Principais autores: Purkayastha, Purboja, Pendyala, Kavya, Saxena, Ayush S, Hakimjavadi, Hesamedin, Chamala, Srikar, Dixit, Purushottam, Baer, Charles F, Lele, Tanmay P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Discoveries
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321517/
https://ncbi.nlm.nih.gov/pubmed/33871606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msab102
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