Piezo2 Knockdown Inhibits Noxious Mechanical Stimulation and NGF-Induced Sensitization in A-Delta Bone Afferent Neurons

Piezo2 is a mechanically gated ion-channel that has a well-defined role in innocuous mechanical sensitivity, but recently has also been suggested to play a role in mechanically induced pain. Here we have explored a role for Piezo2 in mechanically evoked bone nociception in Sprague Dawley rats. We ha...

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Vydáno v:Front Physiol
Hlavní autoři: Nencini, Sara, Morgan, Michael, Thai, Jenny, Jobling, Andrew I., Mazzone, Stuart B., Ivanusic, Jason J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320394/
https://ncbi.nlm.nih.gov/pubmed/34335288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.644929
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