Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

The COVID-19 pandemic poses a global threat to public health and economy. The continuously emerging SARS-CoV-2 variants present a major challenge to the development of antiviral agents and vaccines. In this study, we identified that EK1 and cholesterol-coupled derivative of EK1, EK1C4, as pan-CoV fu...

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Dettagli Bibliografici
Pubblicato in:Signal Transduct Target Ther
Autori principali: Xia, Shuai, Lan, Qiaoshuai, Zhu, Yun, Wang, Chao, Xu, Wei, Li, Yutang, Wang, Lijue, Jiao, Fanke, Zhou, Jie, Hua, Chen, Wang, Qian, Cai, Xia, Wu, Yang, Gao, Jie, Liu, Huan, Sun, Ge, Münch, Jan, Kirchhoff, Frank, Yuan, Zhenghong, Xie, Youhua, Sun, Fei, Jiang, Shibo, Lu, Lu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320318/
https://ncbi.nlm.nih.gov/pubmed/34326308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-021-00712-2
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