MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and lacks definite treatment targets. Tumor immune microenvironment (TIME) heterogeneity has a profound impact on the immunotherapy response. Tumors with non-inflamed TIME derive limited benefit from imm...

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Dettagli Bibliografici
Pubblicato in:J Immunother Cancer
Autori principali: Wu, Si-Yu, Xiao, Yi, Wei, Jin-Li, Xu, Xiao-En, Jin, Xi, Hu, Xin, Li, Da-Qiang, Jiang, Yi-Zhou, Shao, Zhi-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2021
Soggetti:
Clinical/Translational Cancer Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8320259/
https://ncbi.nlm.nih.gov/pubmed/34321275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-002528
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