Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m(6)A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted from Abelmoschus manihot, has been widely used in China to reduce podocyte injury in diabetic kidney disease (DKD). However, the mechanisms underlying the therapeutic action of this compound have yet to be eluc...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Liu, Bu-Hui, Tu, Yue, Ni, Guang-Xia, Yan, Jin, Yue, Liang, Li, Zi-Lin, Wu, Jing-Jing, Cao, Yu-Ting, Wan, Zi-Yue, Sun, Wei, Wan, Yi-Gang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319635/
https://ncbi.nlm.nih.gov/pubmed/34335245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.667644
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