SUMOylation of SAMHD1 at Lysine 595 is required for HIV-1 restriction in non-cycling cells

SAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but not its dNTPase function, implying that additional m...

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發表在:Nat Commun
Main Authors: Martinat, Charlotte, Cormier, Arthur, Tobaly-Tapiero, Joëlle, Palmic, Noé, Casartelli, Nicoletta, Mahboubi, Bijan, Coggins, Si’Ana A., Buchrieser, Julian, Persaud, Mirjana, Diaz-Griffero, Felipe, Espert, Lucile, Bossis, Guillaume, Lesage, Pascale, Schwartz, Olivier, Kim, Baek, Margottin-Goguet, Florence, Saïb, Ali, Zamborlini, Alessia
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8319325/
https://ncbi.nlm.nih.gov/pubmed/34321470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24802-5
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