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Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia
Mitochondria supply ATP essential for neuronal survival and regeneration. Brain injury and ischemia trigger acute mitochondrial damage and a local energy crisis leading to degeneration. Boosting local ATP supply in injured axons is thus critical to meet increased energy demand during nerve repair an...
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| Publicado en: | Curr Biol |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8319057/ https://ncbi.nlm.nih.gov/pubmed/34087103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2021.04.079 |
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