Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

Alveolar epithelial–capillary barrier disruption is a hallmark of acute respiratory distress syndrome (ARDS). Contribution of mitochondrial dysfunction to the compromised alveolar-capillary barrier in ARDS remains unclear. Mesenchymal stromal cells-derived extracellular vesicles (MSC-EVs) are consid...

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Udgivet i:Eur Respir J
Main Authors: Dutra Silva, Johnatas, Su, Yue, Calfee, Carolyn S., Delucchi, Kevin L., Weiss, Daniel, McAuley, Danny F., O'Kane, Cecilia, Krasnodembskaya, Anna D.
Format: Artigo
Sprog:Inglês
Udgivet: European Respiratory Society 2021
Fag:
Original Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318599/
https://ncbi.nlm.nih.gov/pubmed/33334945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1183/13993003.02978-2020
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