Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic form of regulated cell death that has been implicated in maladaptive renal repair in mice and humans. Using single-cell transcriptomic and mouse genetic approaches, we show that proximal tubular (PT) cells de...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ide, Shintaro, Kobayashi, Yoshihiko, Ide, Kana, Strausser, Sarah A, Abe, Koki, Herbek, Savannah, O'Brien, Lori L, Crowley, Steven D, Barisoni, Laura, Tata, Aleksandra, Tata, Purushothama Rao, Souma, Tomokazu
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2021
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318592/
https://ncbi.nlm.nih.gov/pubmed/34279220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.68603
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