Decreased ATM Protein Expression Is Substantiated with PTEN Loss in Defining Aggressive Phenotype of Prostate Cancer Associated with Lethal Disease

BACKGROUND: Ataxia Telangiectasia Mutated (ATM) serine/threonine protein kinase is a known tumor suppressor, involved in DNA damage repair. It has prognostic and predictive therapeutic implications and is associated with aggressive prostate cancer (PCa). OBJECTIVE: To investigate the prognostic valu...

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Detalhes bibliográficos
Publicado no:Eur Urol Open Sci
Main Authors: Walker, Simon R., Abdelsalam, Ramy, Ghosh, Sunita, Livingstone, Julie, Palanisamy, Nallasivam, Boutros, Paul C., Yip, Steven M., Lees-Miller, Susan P., Bismar, Tarek A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Prostate Cancer
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317877/
https://ncbi.nlm.nih.gov/pubmed/34337539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.euros.2021.05.004
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