Urate-induced epigenetic modifications in myeloid cells

OBJECTIVES: Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic processes associated to urate-mediated hyper-responsiveness. METHODS: Freshly isola...

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Publicat a:Arthritis Res Ther
Autors principals: Badii, M., Gaal, O. I., Cleophas, M. C., Klück, V., Davar, R., Habibi, E., Keating, S. T., Novakovic, B., Helsen, M. M., Dalbeth, N., Stamp, L. K., Macartney-Coxson, D., Phipps-Green, A. J., Stunnenberg, H. G., Dinarello, C. A., Merriman, T. R., Netea, M. G., Crişan, T. O., Joosten, L. A. B.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8317351/
https://ncbi.nlm.nih.gov/pubmed/34321071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-021-02580-1
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