Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell

Methamphetamine (METH) is a globally abused, highly addictive stimulant. While investigations of the rewarding and motivational effects of METH have focused on neuronal actions, increasing evidence suggests that METH can also target microglia, the innate immune cells of the central nervous system, c...

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Detalhes bibliográficos
Publicado no:ACS Chem Neurosci
Main Authors: Wang, Xiaohui, Northcutt, Alexis L., Cochran, Thomas A., Zhang, Xiaozheng, Fabisiak, Timothy J., Haas, Mackenzie E., Amat, Jose, Li, Hongyuan, Rice, Kenner C., Maier, Steven F., Bachtell, Ryan K., Hutchinson, Mark R., Watkins, Linda R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316980/
https://ncbi.nlm.nih.gov/pubmed/31282647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.9b00225
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