PF-06409577 Activates AMPK Signaling and Inhibits Osteosarcoma Cell Growth

Osteosarcoma (OS) is a common primary bone malignancy. We here investigated the potential activity of PF-06409577, a novel, potent, and direct activator of AMP-activated protein kinase (AMPK), against human OS cells. In established (U2OS, MG-63, and SaOs-2 lines) and primary human OS cells, PF-06409...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Zhu, Yun-Rong, Zhang, Xiang-Yang, Wu, Qiu-Ping, Yu, Cheng-Jian, Liu, Yuan-Yuan, Zhang, Yun-Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316637/
https://ncbi.nlm.nih.gov/pubmed/34336655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.659181
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