Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis

Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem counterproductive. We developed a treatment for...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: AuYeung, Amanda W. K., Mould, Robert C., Stegelmeier, Ashley A., van Vloten, Jacob P., Karimi, Khalil, Woods, J. Paul, Petrik, James J., Wood, Geoffrey A., Bridle, Byram W.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316323/
https://ncbi.nlm.nih.gov/pubmed/34315959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94483-z
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados