Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis

Vaccination can prevent viral infections via virus-specific T cells, among other mechanisms. A goal of oncolytic virotherapy is replication of oncolytic viruses (OVs) in tumors, so pre-existing T cell immunity against an OV-encoded transgene would seem counterproductive. We developed a treatment for...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: AuYeung, Amanda W. K., Mould, Robert C., Stegelmeier, Ashley A., van Vloten, Jacob P., Karimi, Khalil, Woods, J. Paul, Petrik, James J., Wood, Geoffrey A., Bridle, Byram W.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316323/
https://ncbi.nlm.nih.gov/pubmed/34315959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-94483-z
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