Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning

Torsade de Pointes (TdP), a rare but lethal ventricular arrhythmia, is a toxic side effect of many drugs. To assess TdP risk, safety regulatory guidelines require quantification of hERG channel block in vitro and QT interval prolongation in vivo for all new therapeutic compounds. Unfortunately, thes...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Iseppe, Alex Fogli, Ni, Haibo, Zhu, Sicheng, Zhang, Xianwei, Coppini, Raffaele, Yang, Pei-Chi, Srivatsa, Uma, Clancy, Colleen E., Edwards, Andrew G., Morotti, Stefano, Grandi, Eleonora
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316283/
https://ncbi.nlm.nih.gov/pubmed/33772748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2240
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