Myeloid dendritic cells are major producers of interferon-β in dermatomyositis and may contribute to hydroxychloroquine refractoriness

Dermatomyositis pathogenesis remains incompletely understood, however recent work suggests a predominant type 1 IFN response. We explored dermatomyositis pathogenesis by quantifying inflammatory cells in skin, comparing myeloid versus plasmacytoid dendritic cell release of IFN-β, and assessing myelo...

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Veröffentlicht in:J Invest Dermatol
Hauptverfasser: Chen, Kristen L., Patel, Jay, Zeidi, Majid, Wysocka, Maria, Bashir, Muhammad M., Patel, Basil, Maddukuri, Spandana, White, Barbara, Werth, Victoria P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316264/
https://ncbi.nlm.nih.gov/pubmed/33675790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.12.032
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