Phase II study of trifluridine/tipiracil (TAS-102) therapy in elderly patients with colorectal cancer (T-CORE1401): geriatric assessment tools and plasma drug concentrations as possible predictive biomarkers

PURPOSE: The current study aimed to determine the efficacy of trifluridine/tipiracil for elderly patients with advanced colorectal cancer. METHODS: This single-arm, open-label, multicenter, phase II study included elderly patients aged 65 years or more who had fluoropyrimidine-refractory advanced co...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: Takahashi, Masanobu, Sakamoto, Yasuhiro, Ohori, Hisatsugu, Tsuji, Yasushi, Kuroki, Michio, Kato, Satoshi, Otsuka, Kazunori, Komine, Keigo, Takahashi, Masahiro, Takahashi, Shin, Shirota, Hidekazu, Ouchi, Kota, Takahashi, Yoshikazu, Imai, Hiroo, Shibata, Hiroyuki, Yoshioka, Takashi, Tanaka, Masaki, Yamaguchi, Hiroaki, Yamaguchi, Takuhiro, Shimodaira, Hideki, Ishioka, Chikashi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316169/
https://ncbi.nlm.nih.gov/pubmed/34028598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-021-04277-3
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