Emergence of Resistance to Ceftazidime-Avibactam in a Pseudomonas aeruginosa Isolate Producing Derepressed bla(PDC) in a Hollow-Fiber Infection Model

Ceftazidime (CAZ)-avibactam (AVI) is a β-lactam/β-lactamase inhibitor combination with activity against type A and type C β-lactamases. Resistance emergence has been seen, with multiple mechanisms accounting for the resistance. We performed four experiments in the dynamic hollow-fiber infection mode...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Drusano, G. L., Bonomo, Robert A., Marshall, Steven M., Rojas, Laura J., Adams, Mark D., Mojica, Maria F., Kreiswirth, Barry N., Chen, Liang, Mtchedlidze, Nino, Bacci, Meredith, Vicchiarelli, Michael, Bulitta, Jürgen B., Louie, Arnold
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8316140/
https://ncbi.nlm.nih.gov/pubmed/33782013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00124-21
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