Excessive adventitial stress drives inflammation-mediated fibrosis in hypertensive aortic remodelling in mice

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To identify immuno-mechanical mechanisms responsible for differential remodelling, we studied thoracic aortas from 129S6/SvEvTac and C57BL/6 J mice before and after continuous 14-day angiotensin II infusion, which...

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Dades bibliogràfiques
Publicat a:J R Soc Interface
Autors principals: Spronck, Bart, Latorre, Marcos, Wang, Mo, Mehta, Sameet, Caulk, Alexander W., Ren, Pengwei, Ramachandra, Abhay B., Murtada, Sae-Il, Rojas, Alexia, He, Chang-Shun, Jiang, Bo, Bersi, Matthew R., Tellides, George, Humphrey, Jay D.
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2021
Matèries:
Life Sciences–Engineering interface
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315831/
https://ncbi.nlm.nih.gov/pubmed/34314650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsif.2021.0336
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