Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

BACKGROUND: Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse o...

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Vydáno v:Lancet Respir Med
Hlavní autoři: Butler, Christopher C, Yu, Ly-Mee, Dorward, Jienchi, Gbinigie, Oghenekome, Hayward, Gail, Saville, Benjamin R, Van Hecke, Oliver, Berry, Nicholas, Detry, Michelle A, Saunders, Christina, Fitzgerald, Mark, Harris, Victoria, Djukanovic, Ratko, Gadola, Stephan, Kirkpatrick, John, de Lusignan, Simon, Ogburn, Emma, Evans, Philip H, Thomas, Nicholas P B, Patel, Mahendra G, Hobbs, F D Richard
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Ltd. 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315758/
https://ncbi.nlm.nih.gov/pubmed/34329624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S2213-2600(21)00310-6
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