Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration

Genetics plays a role in age-related macular degeneration (AMD), a common cause of blindness in the elderly. There is a need for powerful methods for carrying out region-based association tests between a dichotomous trait like AMD and genetic variants on family data. Here, we apply our new generaliz...

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Vydáno v:J Am Stat Assoc
Hlavní autoři: Jiang, Yingda, Chiu, Chi-Yang, Yan, Qi, Chen, Wei, Gorin, Michael B., Conley, Yvette P., Lakhal-Chaieb, M’Hamed Lajmi, Cook, Richard J., Amos, Christopher I., Wilson, Alexander F., Bailey-Wilson, Joan E., McMahon, Francis J., Vazquez, Ana I., Yuan, Ao, Zhong, Xiaogang, Xiong, Momiao, Weeks, Daniel E., Fan, Ruzong
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315575/
https://ncbi.nlm.nih.gov/pubmed/34321704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/01621459.2020.1799809
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