Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis

In a cohort of infants, we found that lack of the Lewis histo-blood group antigen was associated with increased susceptibility to shigellosis. Broadly inhibiting fucosylation in epithelial cells in vitro decreased invasion by Shigella flexneri. These results support a role for fucosylated glycans in...

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Udgivet i:Clin Infect Dis
Main Authors: Leslie, Jhansi L, Weddle, Erin, Yum, Lauren K, Lin, Ye, Jenior, Matthew L, Lee, Benjamin, Ma, Jennie Z, Kirkpatrick, Beth D, Nayak, Uma, Platts-Mills, James A, Agaisse, Herve F, Haque, Rashidul, Petri, William A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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Online Only Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315233/
https://ncbi.nlm.nih.gov/pubmed/32940644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cid/ciaa1409
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