The Spleen Tyrosine Kinase Inhibitor, Entospletinib (GS-9973) Restores Chemosensitivity in Lung Cancer Cells by Modulating ABCG2-mediated Multidrug Resistance

Tyrosine kinase inhibitors (TKIs) are important in managing lymphoid malignancies by targeting B-cell receptor signaling pathways. Entospletinib (GS-9973) is an oral, selective inhibitor of spleen tyrosine kinase (Syk), currently in the phase II clinical trials for the treatment of chronic lymphocyt...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Narayanan, Silpa, Wu, Zhuo-Xun, Wang, Jing-Quan, Ma, Hansu, Acharekar, Nikita, Koya, Jagadish, Yoganathan, Sabesan, Fang, Shuo, Chen, Zhe-Sheng, Pan, Yihang
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8315011/
https://ncbi.nlm.nih.gov/pubmed/34326700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.61229
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