Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonization and growth in the upper respiratory tract. We i...

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Dades bibliogràfiques
Publicat a:Emerg Infect Dis
Autors principals: Soumana, Illiassou Hamidou, Linz, Bodo, Dewan, Kalyan K., Sarr, Demba, Gestal, Monica C., Howard, Laura K., Caulfield, Amanda D., Rada, Balázs, Harvill, Eric T.
Format: Artigo
Idioma:Inglês
Publicat: Centers for Disease Control and Prevention 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314809/
https://ncbi.nlm.nih.gov/pubmed/34286682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3201/eid2708.203566
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