Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonization and growth in the upper respiratory tract. We i...

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Detalhes bibliográficos
Publicado no:Emerg Infect Dis
Main Authors: Soumana, Illiassou Hamidou, Linz, Bodo, Dewan, Kalyan K., Sarr, Demba, Gestal, Monica C., Howard, Laura K., Caulfield, Amanda D., Rada, Balázs, Harvill, Eric T.
Formato: Artigo
Idioma:Inglês
Publicado em: Centers for Disease Control and Prevention 2021
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314809/
https://ncbi.nlm.nih.gov/pubmed/34286682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3201/eid2708.203566
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