Modeling Immune Evasion and Vaccine Limitations by Targeted Nasopharyngeal Bordetella pertussis Inoculation in Mice

Conventional pertussis animal models deliver hundreds of thousands of Bordetella pertussis bacteria deep into the lungs, rapidly inducing severe pneumonic pathology and a robust immune response. However, human infections usually begin with colonization and growth in the upper respiratory tract. We i...

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Detaylı Bibliyografya
Yayımlandı:Emerg Infect Dis
Asıl Yazarlar: Soumana, Illiassou Hamidou, Linz, Bodo, Dewan, Kalyan K., Sarr, Demba, Gestal, Monica C., Howard, Laura K., Caulfield, Amanda D., Rada, Balázs, Harvill, Eric T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Centers for Disease Control and Prevention 2021
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8314809/
https://ncbi.nlm.nih.gov/pubmed/34286682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3201/eid2708.203566
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