Acute TBK1/IKK-ε Inhibition Enhances the Generation of Disease-Associated Microglia-Like Phenotype Upon Cortical Stab-Wound Injury

Traumatic brain injury has a poorer prognosis in elderly patients, possibly because of the enhanced inflammatory response characteristic of advanced age, known as “inflammaging.” Recently, reduced activation of the TANK-Binding-Kinase 1 (Tbk1) pathway has been linked to age-associated neurodegenerat...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Rehman, Rida, Tar, Lilla, Olamide, Adeyemi Jubril, Li, Zhenghui, Kassubek, Jan, Böckers, Tobias, Weishaupt, Jochen, Ludolph, Albert, Wiesner, Diana, Roselli, Francesco
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313992/
https://ncbi.nlm.nih.gov/pubmed/34326766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.684171
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