HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity

Heme oxygenase-1 (HO-1) has attracted accumulating attention for its antioxidant enzymatic activity. However, the exact regulatory role of its non-enzymatic activity in the cardiovascular system remains unaddressed. Here, we show that HO-1 was accumulated in the nuclei of stress-induced senescent en...

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Bibliografske podrobnosti
izdano v:Cell Death Dis
Main Authors: Luo, Wenwei, Li, Jingyan, Li, Ziqing, Lin, Tong, Zhang, Lili, Yang, Wanqi, Mai, Yanqi, Liu, Ruiming, Chen, Meiting, Dai, Chunmei, Yang, Hanwei, Lu, Jing, Li, Hong, Guan, Guimei, Huang, Min, Liu, Peiqing, Li, Zhuoming
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8313700/
https://ncbi.nlm.nih.gov/pubmed/34312365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-04035-6
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