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Preferential Light-Chain Labeling of Native Monoclonal Antibodies Improves the Properties of Fluorophore Conjugates

Site specific labeling methods have significant potential to enhance the properties of antibody conjugates. While studied extensively in the context of antibody-drug conjugates (ADCs), few studies have examined the impact of homogenous labeling on the properties of antibody-fluorophore conjugates (A...

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Publicat a:Tetrahedron Lett
Autors principals: Luciano, Michael P., Dingle, Ivan, Nourian, Saghar, Schnermann, Martin J.
Format: Artigo
Idioma:Inglês
Publicat: 2021
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8312683/
https://ncbi.nlm.nih.gov/pubmed/34321699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2021.153211
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